Exercise limitations in COPD – more inhalers?

chronic pulmonary obstruction (chronic obstructive pulmonary disease) is defined by Airway obstruction and alveolar damage due to exposure to harmful air particles. Physiological findings include varying degrees of gas exchange abnormalities and mechanical respiratory limitations, often in the form of dynamic hyperinflation. There is a third major factor, though. This is correct, Removal of skeletal muscle conditioning. Only one of these abnormalities responds to inhalers.

When patients with COPD report shortness of breath or exercise intolerance, what do you do? Are you trying to identify her character to determine her origin? Do you ask them about their baseline activity levels to determine how conditioned they are? I bet you got right to the point and ordered a CPET. This way you will be able to provoke a provocation to all of the contributors. Nah. Most likely add a file inhaler Before continuing to accelerate COPD quality measures: Vaccines? examines. Lung cancer screening? examines. Quit Smoking? examines.

Physiology From Dyspnea and exercise restrictions in COPD It was It has been extensively studied. Breathing action, dynamic hyperinflation, and inefficient gas exchange interact with each other in complex ways to produce symptoms. The presence of a lack of conditioning simply amplifies the abnormalities within the respiratory system by creating more pressure at lower work rates. Acute exacerbations (AECOPD) and oral corticosteroids Exacerbation of skeletal muscle weakness.

The Global strategy report for the diagnosis, management and prevention of chronic obstructive pulmonary disease Doctors direct to use inhalers to manage shortness of breath. If they are already using one inhaler, they will get another. This continues until you have settled on a long-acting beta agonist (LABA), a long-acting muscarinic antagonist (LAMA), and Inhaled corticosteroid (ICS). GOLD Report also advises Pulmonary rehabilitation For any patient with grade B to D disease. Unfortunately, the recommendation for pulmonary rehabilitation is buried in the text and does not appear within the common drug algorithms in the report numbers.

The data on adding inhalers on top of each other to reduce AECOPD and improve overall quality of life (QOL) is good. However, although GOLD tells us to continue adding inhalers to a dyspnoea patient with COPD, the authors acknowledge that this has not been systematically tested. It is important to remember that GOLD is a “statement” rather than a clinical practice guideline. the difference? The statement does not require the same rigorous formal scientific analysis known as THE GRADE APPROACH. Using this type of analysis, a Modern Clinical Practice Guidelines by the American Thoracic Society No benefit was found in dyspnea or respiratory QOL with escalation of inhaled monotherapy.

Inhalers won’t do anything if gas exchange is inefficient and de-conditioning, at least not directly. a Recent CPET Study from CanCOLD Network Ventilator inefficiency was found in 23% of GOLD 1 and 26% of GOLD 2 to 4 COPD patients. The numbers were higher for those who reported shortness of breath. Rates of muscular and skeletal weakness are equally high.

Thus, shortness of breath and exercise intolerance are major determinants of QOL in COPD, but inhalers will only help you. At a minimum, make sure you have Activity/exercise history from your patients with COPD. For those who are stable, provide Prescription (Actually, it’s not that hard to do.) If dyspnea persists despite LABA or LAMA monotherapy, clear up the complaint before doubling in size. Finally, try to get the patient into a good pulmonary rehabilitation program. They will thank you then.

Aaron B. Holley, MD, is an assistant professor of medicine at Uniformed Services and director of the Pulmonary and Critical Care Medicine Program at Walter Reed National Military Medical Center. covers a A wide range of topics in pulmonology, critical care and sleep medicine.

Follow Medscape on FacebookAnd the TwitterAnd the InstagramAnd the Youtube